Drug points: Ocular damage associated with proton pump inhibitors
- 21 June 1997
- Vol. 314 (7097) , 1805
- https://doi.org/10.1136/bmj.314.7097.1805
Abstract
Ocular damage has been associated with the intravenous use of high doses of omeprazole. A pharmacoepidemiological study recently found no association between omeprazole and impaired vision in a population of about 95 000.1 However, our monitoring unit for serious adverse drug reactions in Bremen has registered nine cases of impaired vision associated with the use of omeprazole, but none with other antiulcer drugs such as H2 receptor antagonists (table 1). Six cases were funduscopically confirmed irreversible anterior ischaemic optic neuropathy. Two cases (6 and 7) occurred when there were no known risk factors for anterior ischaemic optic neuropathy, oral omeprazole had been taken alone, …Keywords
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