Lithium ion reversibly inhibits inducer‐stimulated adipose conversion of 3T3‐L1 cells
- 22 June 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 218 (1) , 47-51
- https://doi.org/10.1016/0014-5793(87)81015-3
Abstract
Adipose conversion of 3T3‐L1 cells by inducers (dexamethasone, 1‐methyl‐3‐isobutylxanthine and insulin) was inhibited by LiCl at concentrations from 2 to 20 mM. The effect of LiCl was reversible and the inhibited cells were converted to adipocytes when stimulated after the removal of LiCl. Inhibition by LiCl of adipose conversion was accompanied with a blockage of the enhanced [3H]thymidine incorporation and cellular proliferation that occurred before the adipocyte phenotype was expressed. Of the cations tested, only Li+ had these effects.Keywords
This publication has 24 references indexed in Scilit:
- Growth effect of lithium on mouse mammary epithelial cells in serum‐free collagen gel cultureJournal of Cellular Physiology, 1983
- Nicotinamide inhibits adipocyte differentiation of 3T3‐L1 cellsFEBS Letters, 1982
- Growth effects of lithium chloride in BALB/c 3T3 fibroblasts and madin-darby canine kidney epithelial cellsExperimental Cell Research, 1981
- Melittin stimulates Na entry, Na-K pump activity and DNA synthesis in quiescent cultures of mouse cellsCell, 1981
- MONOVALENT ION FLUXES AND THE CONTROL OF CELL PROLIFERATION IN CULTURED FIBROBLASTSAnnals of the New York Academy of Sciences, 1980
- Lithium: a Modulator of Cyclic AMP-Dependent Events in Lymphocytes?Science, 1979
- Spontaneous heritable changes leading to increased adipose conversion in 3T3 cellsCell, 1976
- An established pre-adipose cell line and its differentiation in cultureCell, 1974
- The effect of NaCl and LiCl on vasopressin-sensitive adenyl cyclaseLife Sciences, 1970
- QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINESThe Journal of cell biology, 1963