Effects of Hexachlorocyclohexane (HCH) on the Contractile Response Induced by Norepinephrine in the Rat Isolated Vas deferens

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Abstract
Effects of hexachlorocyclohexane (Technical HCH) on the contractile responses of rat isolated Vas deferens to norepinephrine (NE) were investigated by varying the Ca++and Mg++concentrations of the incubation medium. Preparations incubated in excess Ca++(4.2 mM) or in Ca++‐free Krebs solution showed decrease in sensitivity to NE. The inhibitory action of HCH reduced the sensitivity and decreased maximum responses to NE in any Mg++concentration of the medium. In the normal Ca++and its deficient medium decrease in sensitivity to HCH and the relevant maximum response to NE were observed. In excess Ca++, the HCH effect depressed corresponding to its maximal response to NE. The presence of EDTA depressed the HCH effect irrespective of the Ca++influence on the receptors.