Naturally Occurring Extended-Spectrum Cephalosporinases in Escherichia coli
- 1 July 2006
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (7) , 2573-2576
- https://doi.org/10.1128/aac.01633-05
Abstract
Genetic and functional characterization of the cephalosporinases produced by 65 clonally unrelated clinical Escherichia coli isolates revealed genetic diversity of the ampC genes and showed that Gln287, Cys287, Pro296, Leu298, and Phe350 substitutions were involved in extension of the hydrolysis spectrum to include ceftazidime and cefepime.Keywords
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