Homologous ribosomal proteins in bacteria, yeast, and humans.
- 1 September 1986
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 83 (18) , 6907-6911
- https://doi.org/10.1073/pnas.83.18.6907
Abstract
We describe sequences of two human ribosomal proteins, S14 and S17, and messenger RNAs that encode them. cDNAs were used as molecular hybridization probes to recognize complementary genes in rodent, Drosophila, and yeast chromosomal DNAs. Human ribosomal protein sequences are compared to analogous Chinese hamster, yeast, and bacterial genes. Our observations suggest that some ribosomal protein genes have been conserved stringently in the several phylogenetic lines examined. These genes apparently were established early in evolution and encode products that are fundamental to the translational apparatus. Other ribosomal protein genes examined, although similar enought to heterologous DNA sequences to indicate their structural relationships, appears to have diverged substantially during evolution, probably reflecting adaptations to different genetic environments.This publication has 32 references indexed in Scilit:
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