THE ANTERIOR PITUITARY GLAND AND PROTEIN METABOLISM

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Abstract
It has been realized for some years that treatment with anterior pituitary extract may be followed, under some conditions, by a positive nitrogen balance [Teel & Cushing, 1930; Gaebler, 1933; Lee & Schaffer, 1934] and a fall in the non-protein nitrogen content of the blood [Teel & Watkins, 1929]. As might be expected such effects are associated with growthpromoting fractions of the anterior pituitary lobe. Evidence is now accumulating which relates the influence of anterior lobe preparations on growth and nitrogen retention with their action on carbohydrate metabolism. Thus Shipley & Long [1938] and Young [1939a] found that anterior pituitary fractions which possess diabetogenic activity are also growth-promoting, while more recently Dohan, Fish & Lukens [1941] found that dogs which are in the process of being made permanently diabetic as the result of treatment with crude anterior pituitary extract, exhibit nitrogen retention during those periods in which there was

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