Über die gerichtete Aufnahme des Biopterins im Organismus I.

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Abstract
C14 labelled Biopterin and Neopterin, when fed to larval stages of Queen and Worker bees, behave similarly and are incorporated into different organs. During metamorphosis and imaginal development, the accumulation of the radioactive pterins is found in places of high metabolic activity such as the eyes, wings, legs. They are also found in the tracheal epithelium, in the wing muscles and the ovaries. In tissues of high cellular activity the radioactivity is found in the nuclei. The concentration of the administered labelled Biopterin and Neopterin into the imaginal cuticle at the time of sclerotization and pigmentation, as well as their directed uptake by the peripheral ganglion sheath of the central nervous system points to the functional importance of these pterins as cofactors of phenylalanine hydroxylase and respectively of tryptophane hydroxylase in insects.

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