LAURENCE-MOON-BIEDL SYNDROME
- 1 July 1942
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 28 (1) , 12-16
- https://doi.org/10.1001/archopht.1942.00880070024002
Abstract
The Laurence-Moon-Biedl syndrome consists of retinitis pigmentosa, obesity, hypogenitalism, polydactylism and mental retardation. The literature on the condition up to 1939 has been collected by Cockayne, Krestin and Sorsby1(1935) and Sorsby, Avery and Cockayne2(1939), and among over 150 cases these authors found the disease reported only in the Caucasian race, with the exception of 2 cases among the Japanese and 1 from Egypt. It is therefore considered worth while to describe a case occurring in a Negro family (fig. 1). The sibship consists of seven females and one male. The seventh child, Margaret P. (patient 1), showed four of the five parts of the Laurence-Moon-Biedl syndrome, having no evidence of hypogenitalism. In addition she had nystagmus and bilateral macular degeneration. The third child, Mary P. (patient 2), showed related abnormalities, consisting of bilateral macular degeneration and skeletal defects, not coming under the classification of the Laurence-Moon-BiedlKeywords
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