Interleukin‐4 inhibits the expression of tumour necrosis factors α and β, interleukins‐1 β and ‐6 and interferon‐γ
- 1 February 1995
- journal article
- Published by Wiley in Immunology & Cell Biology
- Vol. 73 (1) , 57-61
- https://doi.org/10.1038/icb.1995.9
Abstract
T cell-derived IL-4 inhibits the expression of several inflammatory cytokine genes. In this study, IL-4 downregulated TNF- and -. IL-1 IL-6 and IFN- steady-state mRNA and protein production by blood leucocytes. In a detailed kinetic analysis, cytokine mRNA levels were significantly decreased in the presence of IL-4, suggesting an early and prolonged down regulatory effect. These findings support the general thesis that IL-4 is an important regulator of the inflammatory immune response.Keywords
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