Concise Synthesis and Enzymatic Resolution of L-(+)-Homophenylalanine Hydrochloride
- 1 January 2002
- journal article
- research article
- Published by Taylor & Francis in Enantiomer: A Journal of Sterochemistry
- Vol. 7 (1) , 1-3
- https://doi.org/10.1080/10242430210706
Abstract
The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase . Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.Keywords
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