Aripiprazole: profile on efficacy and safety

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Abstract
Aripiprazole (Abilitat™, Bristol-Myers Squibb) is the most recent addition to the new class of atypical antipsychotic medications, following the release of clozapine, risperidone, olanzapine, quetiapine and ziprasidone. Aripiprazole exhibits typical antagonism at dopamine (D2) receptors in the mesolimbic pathway, as well as having unique partial agonist activity at D2 receptors in the mesocortical pathway. As exemplified by other atypical antipsychotics, it displays strong 5-HT2a receptor antagonism and is similar to ziprasidone in also having agonistic activity at the 5-HT1a receptor. Among the atypical antipsychotics, aripiprazole displays the lowest affinity for α1adrenergic (α1), histamine (H1) and muscarinic (M1) receptors. This combination of effects may be responsible for its efficacy in positive and negative symptoms of schizophrenia and in bipolar disorder. Similarly, this profile may be the reason for the low rates of reported side effects observed. This includes general adverse events, a low in...

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