GLYCOSYLATED HEMOGLOBIN DETERMINATION FROM CAPILLARY BLOOD SAMPLES

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Abstract
Ferrell, R. E. (Graduate School of Biomedlcal Sciences, P.O. Box 20334, Houston, TX 77225), C. L. Hanis, L. Agullar, B. Tulloch, C. Garcia and W. J. Schull. Glycosylated hemoglobin determination from capillary blood samples: utility in an epldemlologlc survey of diabetes. Am J Epidemiol 1984; 119: 159–66. Total glycosylated hemoglobin was measured from capillary blood specimens obtained from a sample of 1880 individuals of Mexican-American ancestry residing in Starr County, Texas, between January 1981 and February 1982, as part of an epidemiologic survey to assess the prevalence of non-insulln-dependent diabetes mellltus (Type ii). No significant difference was found between males and females. Diabetics were found to have significantly higher levels of glycosylated hemoglobin than nondiabetics. However, among diabetics, there was no significant difference between newly diagnosed and known diabetics, and known diabetics taking medication did not differ significantly from those not taking medication. An analysis of the specificity and sensitivity of glycosylated hemoglobin, fasting blood glucose, and casual blood glucose determinations as screening devices in a survey of diabetes prevalence reveals that glycosylated hemoglobin is superior to casual blood glucose determination. The conditions under which various screening devices might be more effective are discussed.