Effects of carcinogens and partial hepatectomy upon the hepatic O6-methylguanine repair system in mice

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Abstract
The enhanced repair of O 6 -methylguanine from hepatic DNA in rats is a well established phenomenon that can be induced by pretreatment with a variety of hepatotoxic agents as well as by partial hepatectomy. Attempts to induce a similar hepatic response by treatment with single doses of aflatoxin B 1 in C57Bl mice, single doses of dimethylnitrosamine (DMN) in C57BI or BALB/C mice or by prolonged pretreatment with DMN by addition to the drinking water of C57Bl mice were uniformly unsuccessful. Furthermore, the intense proliferative response induced by two-thirds partial hepatectomy in C57Bl mice was also apparently incapable of increasing the activity of this repair function. These experiments, in which repair of O 6 -methylguanine has been determined both in vivo after administration of [ 14 C]DMN and in vitro using crude tissue extracts and a methylated DNA substrate, indicate the presence of an intergeneric difference between rats and mice with respect to this repair function.

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