ANTIGEN-PULSED NEUTROPHILS BEARING Ia ANTIGENS CAN INDUCE T LYMPHOCYTE PROLIFERATIVE RESPONSE TO THE SYNGENEIC OR SEMISYNGENEIC ANTIGEN-PRIMED T LYMPHOCYTES

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Abstract
Antigen-pulsed neutrophils from mouse peritoneal cavities displayed a remarkable level of lymphocyte proliferative activities to antigen-primed T lymphocytes. Genetic mapping studies demonstrated that compatibility at the I-A and I-E/C subregions of the major histocompatibility complex (MHC) was essential for effective presentation of the lysozyme antigen. These antigen-presenting activities were remarkably inhibited by anti-Ia sera. Inhibition tests revealed that neutrophil Ia antigens seem to be essential for antigen presentation during the initial 8 h. Elimination studies of antigen-pulsed neutrophils with alloantisera plus complement revealed these antigen-presenting neutrophils bearing I-A and I-E/C gene products on the same cells. Ia-positive neutrophils might play a role in the immune response through antigen presentation.

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