Basis for the Acquisition of Malignant Potential by Mouse Cells Cultivated in vitro
- 29 November 1968
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 162 (3857) , 1024-1026
- https://doi.org/10.1126/science.162.3857.1024
Abstract
Balb/c mouse embryo lines maintained in culture for over 200 generations under conditions that minimize cell-cell contact do not become tumorigenic. Lines cultivated under conditions where there is extensive cell contact become tumor-producing within 30 generations. The tissue-culture property that correlates best with tumorigenicity is the loss of contact inhibition of cell division.Keywords
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