Serum Hyaluronic Acid and Procollagen III Amino Terminal Propeptide in Chronic Renal Failure

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Abstract
Elevated serum concentrations of hyaluronic acid (HA) and procollagen III amino terminal propeptide (PIIINP) have been found in various diseases characterized by altered metabolism of collagen. In the present study, their serum levels were measured in 105 renal patients and 22 normal controls. Median HA concentrations were 23 µg/l in controls, 47 µg/l in patients with chronic renal failure (CRF, not on dialysis; p 2microglobulin but not with serum alkaline phosphatase or C-terminal parathormone. Serum HA did not change significantly during hemodialysis treatment and was independent of the type of dialyzer membrane material. Median PIIINP values were 2.7 µg/l in controls, 4.4 µg/l in patients with CRF (p

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