GOLD THERAPY FOR RHEUMATOID ARTHRITIS: A CURRENT EVALUATION

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Abstract
Observations and conclusions are based upon a review of pertinent literature for the past 25 yrs. and analysis of 26 cases treated by the author during the past 8 yrs. There is a brief summary describing the development of this form of treatment, followed by a discussion of hypotheses regarding its mode of action, indications and contra-indications, results to be expected, management of the individual patient, and toxic reactions and their treatment. Most investigators who have studied the problem impartially have recognized the value of chrysotherapy for rheumatoid arthritis. Best results may be obtained by the admn. of small doses at weekly intervals for 4 months unless reactions occur. Thereafter a maintenance dose may be given every 4 or 5 weeks for indefinite periods, depending upon the response of the patient. If patients are carefully observed for renal, gastrointestinal, dermatologic and hematologic alterations, description and treatment of which are discussed, serious reactions can be avoided. Au salts continue to be a useful tool in the treatment of rheumatoid arthritis in spite of the more dramatic, less enduring anti-rheumatic effects of ACTH and cortisone.