Antigenic Composition of Recombinant Virus Strains Produced from Human and Avian Influenza A Viruses
Open Access
- 1 July 1969
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 5 (1) , 83-91
- https://doi.org/10.1099/0022-1317-5-1-83
Abstract
The antigenic structure of a recombinant virus, FPV-A2 (r4), obtained by the interaction of an avian and a human influenza A virus was investigated by means of haemagglutination-inhibition, neuraminidase-inhibition and immunoprecipitation tests. The neuraminidase of the recombinant was found to be antigenically identical to that of its A2/singapore/1/57 parent whilst its haemagglutinin was identical to that of fowl plague virus, the other parent. Similar studies on a recombinant obtained by the interaction of two avian influenza A virus strains, fowl plague virus and A/turkey/massachusetts/65 virus, indicated that it contained neuraminidase of the antigenic type found in the turkey virus and haemagglutinin like that of fowl plague virus. A/turkey/massachusetts/65 was selected for study since its neuraminidase is antigenically closely related to that of human A2 virus strains.Keywords
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