Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts
Open Access
- 17 November 2003
- journal article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 43 (3) , 277-285
- https://doi.org/10.1093/rheumatology/keh039
Abstract
Objective. Fas-mediated apoptosis is preferentially observed in synoviocytes of patients with rheumatoid arthritis (RA) and is associated with the pathophysiological process of RA. To clarify the molecular mechanisms of Fas-mediated apoptosis of RA synoviocytes, we investigated the role of the mitochondrial pathway and tumour suppressor p53 in this process.Keywords
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