Structural similarities between topoisomerases that cleave one or both DNA strands
Open Access
- 7 July 1998
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 95 (14) , 7876-7881
- https://doi.org/10.1073/pnas.95.14.7876
Abstract
Type IA and type II DNA topoisomerases are distinguished by their ability to cleave one or two strands, respectively, of a DNA duplex. Both types have been proposed to use an “enzyme-bridging” mechanism, in which a break is formed in a DNA strand and a gap is opened between the broken pieces to allow passage of a second DNA strand or duplex segment. Although the type IA and type II topoisomerase structures appear overall quite different from one another, unexpected similarities between several structural elements suggest that members of the two subfamilies may use comparable mechanisms to bind and cleave DNA.Keywords
This publication has 47 references indexed in Scilit:
- The CCP4 suite: programs for protein crystallographyActa Crystallographica Section D-Biological Crystallography, 1994
- Protein Structure Comparison by Alignment of Distance MatricesJournal of Molecular Biology, 1993
- Crystallization of a 67 kDa Fragment of Escherichia coli DNA Topoisomerase IJournal of Molecular Biology, 1993
- Novel ion specificity of a carboxylate cluster magnesium(II) binding site: Strong charge selectivity and weak size selectivityBiochemistry, 1993
- TRANSCRIPTION FACTORS: Structural Families and Principles of DNA RecognitionAnnual Review of Biochemistry, 1992
- Crystal structure of an N-terminal fragment of the DNA gyrase B proteinNature, 1991
- Sensory transduction in bacterial chemotaxis involves phosphotransfer between CHE proteinsBiochemical and Biophysical Research Communications, 1988
- Role of divalent cation in topoisomerase II mediated reactionsBiochemistry, 1987
- Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical featuresBiopolymers, 1983
- Proteins that Affect DNA ConformationAnnual Review of Biochemistry, 1978