ANTERIOR PITUITARY GROWTH HORMONE ADMINISTRATION IN B VITAMIN DEFICIENCIES IN THE RAT

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Abstract
IT HAS been previously reported from this laboratory that administration of anterior pituitary growth hormone to pyaidoxine-deficient rats results in an accentuation of the deficiency syndrome (Beare, Beaton, Smith and McHenry, 1953). Further, the hormone was unable to exert its anabolic properties in rats not provided with pyridoxine but provided with the other essential B vitamins. It was stated that only one vitamin had been studied and that the specificity of effects was not known. The experiments to be reported represent similar investigations employing rats deficient in other members of the vitamin B complex. In both experiments, albino rats of the Wistar strain and of both sexes were employed. All animals were housed in individual screen-bottomed cages during the initial period of experimental feeding and vitamin deprivation. Food and water were provided ad libitum. When vitamin deficiencies were apparent, the respective groups were rebalanced in average body weight and transferred to metabolism cages