Duration of the local anesthetic effect of tetracaine hydrochloride solutions and tetracaine in microspheres.
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 5 (1) , 13-17
- https://doi.org/10.1248/bpb1978.5.13
Abstract
The local anesthetic effect of tetracaine in polylactic acid micropheres was compared with that of tetracaine hydrochloride solutions. The local anesthetic effect of 0.1 ml tetracaine hydrochloride solutions was examined at 4 concentrations in vivo [on guinea-pig skin]. The local anesthetic effect of 0.2 ml tetracaine hydrochloride solutions was compared with that of 0.1 ml tetracaine hydrocholoride solutions. The greater the amount of tetracaine, the stronger and longer was the local anesthetic effect. The local anesthetic effect of tetracaine in microspheres was much longer and lasted over 100 h.This publication has 2 references indexed in Scilit:
- PROLONGED EFFECT OF BUPIVACAINE HYDROCHLORIDE AFTER CUFF RELEASE IN I.V. REGIONAL ANAESTHESIABritish Journal of Anaesthesia, 1980
- A New Long-Acting Injectable Microcapsule System for the Administration of ProgesteroneFertility and Sterility, 1979