PROTEINS IN SERUM AND CEREBROSPINAL FLUID IN DEMENTED PATIENTS

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Abstract
Sixteen plasma proteins, including the immunoglobulins, were determined in cerebrospinal fluid (CSF) and serum from 12 demented patients. Furthermore, the total protein content was measured, haptoglobin was typed and serum was tested for precipitins against water‐extractable human brain antigens. No specific quantitative changes in the plasma proteins in either CSF or serum were found. In CSF, an increased permeability of the blood‐liquor‐barrier, reflected in raised CSF total protein values, dominated the picture. In serum, no changes specific to brain atrophy were found, neither were any precipitins against human brain antigens revealed.