Effet De LaS-Adénosyl-L-Méthionine Sur Le Métabolisme Cérébral Et Périphérique De La L-Dopa(1)

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Abstract
The repartition of [3H]L-dopa administred i.p. does not change in rats treated with 5-adenosyl-L-methionine (SAM). The effect was studied on the central nervous system and at the periphery. The biosynthesis of metabolites [3H]dopamine and [3H]3-O-methyldopamine are also unchanged. On the other hand, in the kidney an accumulation of [3H]norepinephrine +[3H]normetanephrine was observed, while in the brainstem + midbrain the synthesis of these metabolites was decreased after SAM injection. The relations between these biochemical results and the pharmacological antiparkinsonian effects are discussed.