Meiotic delay of mouse spermatocytes carrying x-ray-induced translocations
- 1 January 1992
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 60 (2) , 146-149
- https://doi.org/10.1159/000133326
Abstract
The kinetics of spermatocyte progression through meiotic prophase in cells with or without induced translocations were studied in mice that had been exposed to x-rays. Pulse-labeling experiments using 3H-thymidine, followed by autoradiographic analysis, indicated that at higher x-ray doses (6 and 7 Gy), translocation-carrying cells tend to spend more time in meiotic prophase than do normal cells. At 2 Gy, no such delay seemed to be present. The observed delay may explain the reduction in transmission of translocations to the next generation reported by others.Keywords
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