A hereditary double double-banded variation in the vitamin D-binding protein (GC) system analyzed by immunoblotting: duplication of the 1F and 1A2 genes?

1 April 1989

journal article
research article
Published by Springer Nature in Human Genetics

Vol. 82 (1) , 89-91
https://doi.org/10.1007/bf00288282

Abstract

A combination of immunoblotting and polyacrylamide gel isoelectric focusing (IEF-PAGE) was used to define a new genetic variant in the (GC) group-specific component system. This appeared to be a GC 1-type variant, and was presumed to have arisen from duplication of the GC 1F and GC 1A2 genes.

Keywords

This publication has 15 references indexed in Scilit:

Purification and characterization of a human urine ribonuclease (RNAase 1) showing genetic polymorphism
Biochimica et Biophysica Acta (BBA) - General Subjects, 1988
Forensic application of blood stains and polymorphism of the sixth component of human complement (C6)
Forensic Science International, 1988
Newly characterized genetic polymorphism of uropepsinogen group A (PGA) using both isoelectric focusing and immunoblotting
Human Genetics, 1987
The polymorphism of the vitamin D-binding protein (Gc); Isoelectric focusing in 3 M urea as additional method for identification of genetic variants
Human Genetics, 1983
Gc revisited: Six further Gc-phenotypes delineated by isoelectric focusing and by polyacrylamide gel electrophoresis
Human Genetics, 1981
Affinity differences for the 25‐OH‐D₃ associated with the genetic heterogeneity of the vitamin D‐binding protein
FEBS Letters, 1980
Group-specific component (Gc) polymorphism in Japanese: An analysis by isoelectric focusing on polyacrylamide gels
Journal of Human Genetics, 1979
Neuraminidase treatment reveals sialic acid differences in certain genetic variants of the Gc system (vitamin-D-binding protein)
Human Genetics, 1979
Group-specific component
Human Genetics, 1979
DETECTION OF GENETIC-VARIATION WITH RADIOACTIVE LIGANDS .2. GENETIC-VARIANTS OF VITAMIN-D-LABELED GROUP-SPECIFIC COMPONENT (GC) PROTEINS
1977