THE EFFECT OF IODIDE ON THE RATE OF RELEASE OF I131 FROM AUTONOMOUS THYROID NODULES*

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Abstract
Studies were performed in six patients to ascertain whether iodides are capable of inhibiting the release of organic I131 from Thyroid glands presumably devoid of TSH stimulation. Patients with hyperfunctioning single thyroid nodules were chosen. Suppression tests, scintigrams before and after administration of TSH and studies of iodine metabolism after surgical removal of the nodule provided evidence that secretion of TSH was suppressed in those patients. The rate of disappearance of organic I131 from the nodules of these patients was determined before, during, and after administration of Lugol''s solution. In all instances, fractional disappearance rates were markedly retarded during administration of iodides. It is concluded that iodide is capable of inhibiting the thyroidal secretory process in the absence of concomitant stimulation by TSH.