Über die serologische Spezifität von D- und L-Fucosiden

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Abstract
Human milk contains besides lactose a series of oligosaccharides which contain fucose. Four of these were isolated. Since l-fucose is active in inhibiting the agglutination of human O(H) erythrocytes, an investigation was made to determine whether the fucosides from human milk have the same effect: such activity was expected in view of the fact that blood group substances also contain l-fucose. It was found however that of the fucosides occurring in human milk only fucosido-lactose and a fucose-containing pentasaccharide showed any activity, and that only very slightly. The fucosido-lactose complies with the 3 prerequisites necessary for inhibition of hemagglutination of human O(H) erythrocytes, viz. l-configuration, pyranoside structure and alpha-configuration on carbon atom 1 in the fucosides. In spite of that it occupies an anomalous position in the sequence of substances whose anti-hemagglutinin activity increases from 1-fucose through the alpha-1-fucopy-ranosides to the blood group substances. It is concluded that another constitutional element in the fucose-free moiety is essential for the high activity of the blood group substances.

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