THE BEHAVIOR OF ETHYL IODIDE IN THE BODY

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Abstract
Ethyl iodide is rapidly and completely taken up and given off by blood passing through the lungs. It is constantly present in the venous blood of men and dogs inhaling it and exerts pressure against gases in contact with it. Its destruction in the body is slow and does not equal its rate of absorption under the conditions prescribed for the determination of blood flow. The difference between arterial and venous ethyl iodide concentrations bears no constant relationship to the alveolar concentrations in dogs and men. Ethyl iodide behaves in large part like an indifferent gas and distributes itself in blood and tissues according to its solubility in their various components. Since part of the ethyl iodide is destroyed in blood and tissues, saturation of the body at the concentration inspired is delayed and the difference between arterial and venous concentrations remains large even after prolonged inhalation. The method of Henderson and Haggard for the determination of cardiac output in man is criticized.

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