Comparative effects of cotrimoxazole (trimethoprim‐sulphamethoxazole),pyrimethamine‐sulphadiazine and spiramycin during avirulent infection with Toxoplasma gondii (Beverley strain) in mice

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Abstract
The antitoxoplasm effects of cotrimoxazole (Ctx), spiramycin (Spir) and pyrimethaminesulfadiazine (Pmm-Sdz) were compared during both proliferative and chronic phases of infection of mice with the Beverley (Bev) strain of T. gondii of low virulence. The therapeutic efficacy of the drugs was determined according to the following criteria: specific antibody response; acquired resistance to lethal challenge with the virulent RH strain of Toxoplasma; and persistence of parasites in tissues (brain, liver, spleen) of treated mice. Apparently, Ctx, like Pmm-Sdz, had a greater effect than Spir upon toxoplasma organisms during the proliferative phase of infection. None of the three drugs tested was active aganist tissue cysts in chronically infected mice.