Genetic diversity of the dnaJ gene in the Mycobacterium avium complex
- 1 August 2004
- journal article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 53 (8) , 813-817
- https://doi.org/10.1099/jmm.0.45601-0
Abstract
The Mycobacterium avium complex (MAC) is associated with various diseases in humans as a zoonosis. The dnaJ gene was partially sequenced in Schaefer's 28 reference strains of MAC, 14 human MAC isolates and 22 veterinary isolates. From substitutions affecting 21–32 nucleotides, all strains could be classified into 14 groups. Most nucleotide substitutions did not alter amino acid sequences. Approximately 8 % genetic diversity was seen in these strains, which divided into two clusters: cluster I (0.8 % genetic diversity), comprising the reference strain serotypes 1–6, 8–11 and 21 and all isolates; and cluster II (7 % genetic diversity), comprising the remaining reference strains. Analysis of the dnaJ gene in MAC may be useful in epidemiological studies.Keywords
This publication has 29 references indexed in Scilit:
- Use of the dnaJ Gene for the Detection and Identification of All Legionella pneumophila Serogroups and Description of the Primers Used to Detect 16S rDNA Gene Sequences of Major Members of the Genus LegionellaMicrobiology and Immunology, 2003
- Acid-fast bacteria in the gastric contents of a neonateThe Pediatric Infectious Disease Journal, 2002
- Epidemiology of selected mycobacteria that infect humans and other animalsRevue Scientifique et Technique de l'OIE, 2001
- Relationship between IS901in theMycobacterium aviumComplex Strains Isolated from Birds, Animals, Humans, and the Environment and Virulence for PoultryClinical and Diagnostic Laboratory Immunology, 2000
- Antimycobacterial activities of riminophenazinesJournal of Antimicrobial Chemotherapy, 1999
- Sequence-based differentiation of strains in the Mycobacterium avium complexJournal of Bacteriology, 1993
- Phylogenetic analysis and identification of different serovars of Mycobacterium intracellulare at the molecular levelFEMS Microbiology Letters, 1990
- A gene fromMycobacterium tuberculosiswhich is homologous to the DnaJ heat shock protein ofE.coliNucleic Acids Research, 1988
- The neighbor-joining method: a new method for reconstructing phylogenetic trees.Molecular Biology and Evolution, 1987
- A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesJournal of Molecular Evolution, 1980