PROBUCOL - CHEMICAL-STRUCTURE, PHYSICAL-PROPERTIES AND ASSAY-METHODS
- 1 January 1980
- journal article
- research article
- Vol. 9 (40) , 2973-2975
Abstract
Probucol is isopropylene dithio-4-4'' di (di-tert-butyl-2,6 phenol), a molecule containing 2 atoms of S. Its chemical structure is different from that of other known hypolipemic compounds. Probucol is a white, odorless crystalline powder, almost insoluble in water but soluble in most organic solvents. It is strongly lipophilic. The UV spectrum of probucol in methanol shows maximum absorption at a wavelenght of 242 nm. The finished product is presented as tablets containing 250 mg of probucol. The active substance in the pharmaceutical preparation can be identified by TLC and assayed by UV spectrometry. Human serum levels of probucol can be measured by gas chromatography with electron capture detection, or by mass spectrometry and high pressure liquid chromatography.This publication has 0 references indexed in Scilit: