The process of mRNA–tRNA translocation
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- 11 December 2007
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 104 (50) , 19671-19678
- https://doi.org/10.1073/pnas.0708517104
Abstract
In the elongation cycle of translation, translocation is the process that advances the mRNA–tRNA moiety on the ribosome, to allow the next codon to move into the decoding center. New results obtained by cryoelectron microscopy, interpreted in the light of x-ray structures and kinetic data, allow us to develop a model of the molecular events during translocation.Keywords
This publication has 102 references indexed in Scilit:
- RF3 Induces Ribosomal Conformational Changes Responsible for Dissociation of Class I Release FactorsCell, 2007
- Structures of modified eEF2·80S ribosome complexes reveal the role of GTP hydrolysis in translocationThe EMBO Journal, 2007
- Identification of Two Distinct Hybrid State Intermediates on the RibosomeMolecular Cell, 2007
- Kinetically Competent Intermediates in the Translocation Step of Protein SynthesisMolecular Cell, 2007
- Interactions of the Release Factor RF1 with the Ribosome as Revealed by Cryo-EMJournal of Molecular Biology, 2006
- Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop CodonCell, 2005
- The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coliCell, 2005
- Visualization of release factor 3 on the ribosome during termination of protein synthesisNature, 2004
- Structure of the Escherichia coli ribosomal termination complex with release factor 2Nature, 2003
- Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosomeNature, 1997