γ-Lactam formation from tripeptides with isopenicillin N synthase
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1128-1130
- https://doi.org/10.1039/c39880001128
Abstract
Incubation of isopenicillin N synthase (IPNS) with analogues of the natural substrate [(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine (2) in which the cysteinyl residue was replaced by homocysteine gave epimeric 5-hydroxy γ-lactams (10), with no evidence for the formation of bicyclic products.Keywords
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