Factor VIII:C and VIII:CAg Response in Patients with Haemophilia A and von Willebrand's Disease after Administration of Different Factor VIII Concentrates or Plasma

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Abstract
Factor VIII procoagulant activity (VIII:C) and factor VIII procoagulant antigen (VIII:CAg) were studied in 7 patients with hemophilia A after administration of 3 different factor VIII concentrates or plasma. The in vivo recovery of VIII:CAg was less than that of VIII:C and the disappearance rate of VIII:CAg was much higher when either concentrates or plasma were given. The half-life of VIII:C was about 12 h but of VIII:CAg about .ltoreq. 3 h. Six patients with von Willebrand''s disease were studied after administration of AHF-Kabi. In contrast to hemophilia A the discrepancy between VIII:C and VIII:CAg disappearance rates was not present in von Willebrand''s disease, since both VIII:C and VIII:CAg showed a typical progressive increase. Factor VIII:C given to hemophilia patients does not behave like native VIII:C, not even when fresh plasma is used. Patients with von Willebrand''s disease are capable of forming a normal VIII:C when appropriately stimulated.