Conformational Requirements for Vascular -Adrenergic Activity
- 1 May 1978
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 158 (1) , 28-31
- https://doi.org/10.3181/00379727-158-40132
Abstract
Semi-rigid analogs of trans .alpha.- and .beta.-rotameric conformations of dopamine and epinine were studied for their .alpha.-adrenergic activity on isolated rabbit aortic strips. 2-Amino-6,7-dihydroxytetrahydronaphthalene and its N-methyl derivative (analogous to the trans .beta.-rotamer of dopamine) were 30- to 50-fold more potent than 2-amino-5,6-dihydroxytetrahydronaphthalene and its N-methyl derivatives, respectively, indicating that the trans .beta.-rotamer, rather than the trans .alpha.-rotamer, is the preferred conformation for action on the .alpha.-adrenergic receptors.This publication has 0 references indexed in Scilit: