The Multiple Faces of Glucagon-Like Peptide-1—Obesity, Appetite, and Stress: What Is Next? A Review
- 1 February 2007
- journal article
- review article
- Published by Springer Nature in Digestive Diseases and Sciences
- Vol. 52 (3) , 643-649
- https://doi.org/10.1007/s10620-006-9096-2
Abstract
By itself, glucagon-like peptide-1(GLP-1) appears to be an excellent drug for appetite control and the treatment of obesity. Unfortunately, few enzymes, such as IV dipeptidyl peptidase and renal excretin, degrade and render GLP-1 inactive within minutes. A receptor agonist, exendin-4, with a longer biological half-life than GLP-1, has been tried. Subcutaneous injection of exendin-4 or continuous IV injection of GLP-1 warrants further research and investigation.Keywords
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