BCG-INDUCED MURINE EFFECTOR CELLS .2. CHARACTERIZATION OF NATURAL KILLER CELLS IN PERITONEAL EXUDATES
- 1 January 1977
- journal article
- research article
- Vol. 119 (3) , 1152-1158
Abstract
Cytotoxic activity in peritoneal exudates harvested from C57BL/6 mice 4-6 days after they had received viable BCG organisms i.p. was associated with a nonadherent, nonphagocytic cell. The cytotoxic cell lacked demonstrable surface immunoglobulin and Thy 1 antigen and bore no readily detectable Fc receptors. Lytic activity was labile at 37.degree. C and diminished after trypsinization of the effector cells. Preincubating effector cells with immune complexes was without effect on lytic expression. The cytolytic activity was probably associated with natural killer (NK) cells, previously described in unimmunized mouse spleens and mesenteric lymph nodes. Whether BCG induced activation of resident NK cells, the de novo production of NK cells or homing into the peritoneum of cells normally resident in other lymphoid tissue is unknown.This publication has 3 references indexed in Scilit:
- STUDIES ON MECHANISM OF LYMPHOCYTE-MEDIATED CYTOLYSIS .9. RELATIONSHIPS BETWEEN ANTIGEN RECOGNITION AND LYTIC EXPRESSION IN KILLER T CELLS1977
- BCG-INDUCED MURINE EFFECTOR CELLS .1. CYTOLYTIC ACTIVITY IN PERITONEAL EXUDATES - EARLY RESPONSE TO BCG1977
- Identification of a cell-surface antigen selectively expressed on the natural killer cell.The Journal of Experimental Medicine, 1977