Pharmacokinetics and pharmacodynamics of alprenolol in the treatment of hypertension

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Abstract
The kinetics of alprenolol, in relation to its effect on blood pressure and plasma renin activity, have been studied in sixteen patients. A within-patient comparison was made between therapy for six weeks with placebo or alprenolol 200 mg thrice daily. Thirteen patients responded to alprenolol by a significant fall in blood pressure. In three other patients treatment did not lower blood pressure. In the group as a whole there was no significant correlation between the fall in systolic, diastolic or mean blood pressure, and the steady-state plasma alprenolol concentration, renin status, or degree of beta blockade. However, the thirteen responsive patients showed a significant relationship (p<0.05 – 0.001) between the log mean steady-state plasma alprenolol concentration and the hypotensive response.