Antagonism of the direct fungicidal action of miconazole by miconazole fungistasis
- 1 June 1988
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 7 (3) , 413-414
- https://doi.org/10.1007/bf01962351
Abstract
A weakly fungistatic concentration of miconazole in lag phase yeast cultures ofCandida albicans antagonized development of phenotypic susceptibility to the direct fungicidal action of high-level (i.e. >10−5 M) miconazole. After development in the absence of drug, maintenance of susceptibility upon continued incubation was also antagonized by low levels of miconazole. This auto-antagonistic effect has important clinical implications.This publication has 9 references indexed in Scilit:
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