Sequential changes of left ventricular function after cineangiography in normal heart and coronary artery disease.

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Abstract
To evaluate the effect of contrast material on left ventricular (LV) function, LV pressure and its 1st derivative were continuously monitored during and after LV cineangiography with Mikro-tip angiocatheters in 15 normal subjects (group 1) and patients with coronary artery disease (CAD) without LV asynergy (group 2, n = 10), with mild asynergy (group 3, n = 12) and severe asynergy (group 4, n = 13). In all 4 groups, systolic hypotension, decrease of negative dP/dt, and prlonged time constant of LV pressure fall (T) were observed in 30 s after dye injection and all these parameters returned to the control value in 2 min. LV end-diastolic pressure (EDP) began to elevate at 1 min, reached its peak at 2 min and stayed elevated for 7 min. Although significant decrease in LV systolic pressure was seen, indexes of LV contractility, peak positive dP/dt and (dP/dt)/DP, showed increase in all groups. No different directional changes of these parameters were observed among 4 groups. The degree of LVEDP elevation was parallel to the diastolic elastic stiffness constant (K) in group 1 (r = 0.64, (P < 0.05)). Systolic hypotension and prolonged relaxation evidently are only transient and elevation of LVEDP after the contrast material injection seems to be the effect of only acute volume overload.