Half chromatid mutations: transmission in humans?
- 1 March 1975
- journal article
- Vol. 27 (2) , 218-23
Abstract
Attention is drawn to the possibility of half chromatid and early somatic mutations and to several implications of these mosaic-yielding events. There is suggestive evidence that spontaneous mutations can result in mosaics. A world-wide cooperative study of Lesch-Nyhan families could determine the extent of half chromatid mutation transmission and early somatic mutation in humans.This publication has 12 references indexed in Scilit:
- Detection of heterozygous carriers of the Lesch-Nyhan syndrome by electrophoresis of hair root lysatesThe Journal of Pediatrics, 1973
- Detection of the Heterozygote in Lesch–Nyhan Disease by Hair-Root AnalysisNew England Journal of Medicine, 1972
- MUTATION IN EUKARYOTESAnnual Review of Genetics, 1971
- Expression of Two X-Linked Genes in Human Hair Follicles of Double HeterozygotesProceedings of the National Academy of Sciences, 1971
- The Detection of Increased Mutation Rates in Human PopulationsPerspectives in Biology and Medicine, 1971
- Lesch-Nyhan Syndrome: Rapid Detection of Heterozygotes by Use of Hair FolliclesScience, 1971
- Mutation and Cancer: Statistical Study of RetinoblastomaProceedings of the National Academy of Sciences, 1971
- Single-allele expression at an X-linked hyperuricemia locus in heterozygous human cells.Proceedings of the National Academy of Sciences, 1968
- X-Linked Hypoxanthine-Guanine Phosphoribosyl Transferase Deficiency: Heterozygote Has Two Clonal PopulationsScience, 1968