Effects of Massive Doses of Testosterone Propionate upon Spermatogenesis

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Abstract
A 30-yr.-old man with faulty spermatogenesis was treated with chorionic and pituitary gonadotrophins and subsequently with a concentrated prep. of testosterone propionate. Pre-medication and post-medication biopsies, together with frequent semen analyses, were used to establish the diagnosis and to evaluate the treatment. The gonadotrophins were ineffectual in increasing the number of sperm cells in the semen. Testosterone propionate was then administered intramusc. as follows: 250 mg. each on 4 consecutive days (June, 1942), total 1000 mg.; 300 mg. each on 5 consecutive days (October, 1942), total 1500 mg.; 600 mg., 600 mg., 1000 mg. and 800 mg. respectively on 4 consecutive days (December, 1942), total 3000 mg. From March 15, 1943 to April 13, 1943 a total of 4500 mg. of tesosterone propionate was given in divided daily doses over a period of 28 days. Inhibition of spermatogenesis resulted as indicated by a total absence of spermatozoa in the semen for a period of 18 days. Spontaneous recovery ensued and comparison of testicular tissue following treatment showed no material change from that taken prior to medication.

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