Zur Biogenese der Alkaloide, II. Abbaustudien an biogenetisch14C-markiertem Ricinin
- 1 January 1962
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 330 (Jahresband) , 58-73
- https://doi.org/10.1515/bchm2.1962.330.1.58
Abstract
A method is reported for the stepwise chemical degradation of ricinin. Approximately 500 mg of ricinin permit the determination of the distribution of C14 in each C atom of the molecule. The isotope distribution was studied in [C14] ricinin preparations, from germinating Ricinus plants which had received injections of generally labelled [C14]lysine, [1-C14]glutamic acid, [2-C14]glutamic acid, [3-C14]aspartic acid, [1-C14]acetate, [2-C14]acetate, [C14]formate, [C14]cyanide, or [C14]hydrogen carbonate. Possible precursors of ricinin are proposed on the basis of the incorporation rates and activity distributions. The pyridone ring probably arises from the condensation of several compounds, one of which contains a C4-unit, closely related to aspartic acid and [2-C14]acetate.Keywords
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