Nevirapine Plasma Exposure Affects both Durability of Viral Suppression and Selection of Nevirapine Primary Resistance Mutations in a Clinical Setting
Open Access
- 1 September 2005
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 49 (9) , 3966-3969
- https://doi.org/10.1128/aac.49.9.3966-3969.2005
Abstract
The relationship between nevirapine plasma concentrations and the durability of both viral suppression (VS) and selection of nevirapine primary resistance mutations (PRMs) was evaluated. A nevirapine trough concentration ( C trough ) of >4,300 ng/ml was found to predict longer VS. Patients with nevirapine C trough s ranging from 3,100 to 4,300 ng/ml had higher probabilities of developing PRMs than those with nevirapine C trough s below and above this concentration interval.Keywords
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