THE EFFECT OF CHOLERESIS ON THE RATE OF EXCRETION OF INTRAVENOUSLY INJECTED BILIRUBIN

Publisher Website
Google Scholar
Abstract
The effect of choleresis on the rate of elimination of intravenously-injected bilirubin from the blood and on the rate of its excretion in the bile was studied in anesthetized dogs. Indirect-reacting bilirubin dissolved in an alkaline soln. (pH 9-10) was injected in doses of 5 and 12 mg. per kg. Choleresis was produced by the constant inj. of a 1% or a 10% Na dehydrocholate soln. at a rate of 1 cc. per min. The production of choleresis by the continuous intraven. inj. of Na dehydrocholate did not increase the rate of removal of intravenously injected bilirubin from the blood stream or its excretion in the bile. Whole dog bile as a source of bile pigment was also injected with and without Na dehydrocholate. Similar results were obtained as with pure bilirubin. When large concs. of bilirubin (12 mg. per kg) and Na dehydrocholate (10%) were injected simultaneously, a hyperbilirubinemia without jaundice was converted into a hyperbilirubinemia with jaundice. Possible explanations for this result were discussed. Results do not necessarily rule out the possible beneficial action of a choleretic in increasing the rate of excretion of bile pigment and the disappearance of jaundice after the relief of a common-duct obstruction.

This publication has 1 reference indexed in Scilit: