STUDIES ON WATER METABOLISM IN NORMAL AND HYPOPHYSECTOMIZED FROGS

Abstract
Frogs, hypophysectomized 1-4 wks. before the exp., when injected with obstetrical pituitrin (Parke-Davis), 0.1 cc. per 10 gm. body wt., showed no increase in wt. above control frogs kept in the same water. Normal unoperated frogs kept in the same environment and similarly injected with pituitrin increased ca 18% in wt., reaching their maximal wt. in 4 hrs. with a gradual return to normal. Frogs with brain injuries without hypophysectomy increased in wt. similarly to normal frogs after pituitrin injections. The pituitary gland appears to be essential for wt. changes in frogs following injections of pituitrin.

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