TAURINE AND CAMP CONTENT IN THE HEART

  • 1 January 1981
    • journal article
    • research article
    • Vol. 21  (1) , 85-89
Abstract
The mechanism of the decrease of cAMP content in the heart under the effect of taurine was studied. It was shown on a preparation of cytoplasmic membranes isolated from the rat heart that under the effect of taurine (10-6-10-3 M) the activity of phosphodiesterase and adenylate cyclase increases to the maximum by 2.4 and 1.4 times, respectively. Taurine weakens the activation of adenylate cyclase by adrenaline [epinephrine]. The effect of taurine on adenylate cyclase activity diminished under the action of phentolamine and obsidan and is not manifested in the simultaneous presence of both adrenoblocking agents. Taurine obviously changes the content of cAMP in the heart by altering the activity of adenylate cyclase and phosphodiesterase.

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