Improved syntheses in the pyrimidine series. III. 5‐amino‐4‐methylaminopyrimidine
- 1 February 1954
- journal article
- research article
- Published by Wiley in Journal of Chemical Technology & Biotechnology
- Vol. 4 (2) , 72-75
- https://doi.org/10.1002/jctb.5010040203
Abstract
A synthesis of 5‐amino‐4‐methylaminopyrimidine is reported, which involves the successful monoamination of 5‐amino‐4: 6‐dichloropyrimidine with methylamine. It is shown, however, that similar monoaminations of 2: 4‐ and 4: 6‐dichloro‐5‐nitropyrimidine (which are possible with ammonia) with methylamine lead only to bismethylamino‐5‐nitropyrimidines. Amination of 2: 4‐dimercapto‐5‐nitropyrimidine with methylamine also gives the diaminated product, but when 2: 4‐dimercapto‐5‐aminopyrimidine is used no reaction takes place.Keywords
This publication has 5 references indexed in Scilit:
- Improved syntheses in the pyrimidine series. II. The preparation of 4:5‐diaminopyrimidineJournal of Chemical Technology & Biotechnology, 1952
- 21. Pteridines. Part I. An unambiguous synthesis of 7 : 8-dihydro-6-hydroxypteridinesJournal of the Chemical Society, 1951
- 354. A new synthesis and the chemical properties of 5-aminopyrimidineJournal of the Chemical Society, 1951
- A Synthesis of 4-Amino-2-thiopyrimidinesJournal of the American Chemical Society, 1949
- A NEW SYNTHESIS OF CYTOSINE AND 5-METHYLCYTOSINEJournal of Biological Chemistry, 1949