Synchronization of Kainate-Induced Epileptic Activity via GABAergic Inhibition in the Superfused Rat HippocampusIn Vivo
Open Access
- 15 June 2003
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 23 (12) , 5337-5341
- https://doi.org/10.1523/jneurosci.23-12-05337.2003
Abstract
We studied cellular mechanisms of synchronization of epileptiform activity induced by kainic acid in a novel preparation of superfused rat hippocampus in vivo. Under urethane anesthesia, kainate induced epileptic population spikes occurring at 30–40 Hz. Pyramidal cells fired exclusively during population spikes with an average probability of 0.34 on rebound of rhythmic GABAA-mediated inhibitory postsynaptic events. Excitatory synaptic events contributed little to seizure activity. Rhythmic epileptiform activity was suppressed by blocking GABAA receptors and was slowed by barbiturates. Thus, GABAergic inhibition is instrumental in synchronizing kainate-induced epileptiform rhythmic activity in the gamma frequency band in the intact hippocampus in vivo.Keywords
This publication has 31 references indexed in Scilit:
- On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in VitroScience, 2002
- Impaired Electrical Signaling Disrupts Gamma Frequency Oscillations in Connexin 36-Deficient MiceNeuron, 2001
- Kainate receptor‐mediated presynaptic inhibition at the mouse hippocampal mossy fibre synapseThe Journal of Physiology, 2000
- Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitroNature, 1998
- Presynaptic modulation of CA3 network activityNature Neuroscience, 1998
- Regulation of glutamate release by presynaptic kainate receptors in the hippocampusNature, 1996
- Synchronization of neuronal activity in hippocampus by individual GABAergic interneuronsNature, 1995
- Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activationNature, 1995
- Epileptogenic Effects of Status EpilepticusEpilepsia, 1993
- Single neurones can initiate synchronized population discharge in the hippocampusNature, 1983